https://doi.org/10.4081/monaldi.2024.3070
The impact of COVID-19 infection on idiopathic pulmonary fibrosis mortality: a systematic review and meta-analysis
Submitted: May 28, 2024
Accepted: September 11, 2024
Published: October 15, 2024
Accepted: September 11, 2024
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PDF_EARLY VIEW: 64
SUPPLEMENTARY MATERIAL: 5
SUPPLEMENTARY MATERIAL: 5
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
COVID-19 has a negative impact on the survival of respiratory patients, especially those with interstitial lung disease. This review aims to better understand the effect of COVID-19 on patients with idiopathic pulmonary fibrosis (IPF). A systematic search of MEDLINE, PubMed, Embase, and Scopus performed from December 2019 up to July 2024 identified relevant studies. Eligibility criteria included English language, sample size ≥10 patients, COVID-19 infection and outcome measures. Two independent reviewers assessed studies using the Newcastle-Ottawa Scale for bias and extracted data. Meta-analysis employed a random-effects model, and the Grading of Recommendations Assessment, Development and Evaluation assessed evidence quality. Outcomes considered were hospitalization, intensive care unit admission, and mortality. Of the 1541 initially identified articles, 6 high-quality studies were included. Meta-analysis revealed a 34% mortality rate [95% confidence interval (CI): 21-48%], 36% hospitalization rate (95% CI: 10-75%), and 31% ICU admission rate (95% CI: 7-71%) among IPF patients with COVID-19. The certainty of evidence was low or very low due to publication bias and heterogeneity. This study underscores the elevated risk of hospitalization and death in IPF patients with COVID-19, emphasizing the vulnerability of this population. Prompt and tailored care is crucial to mitigate the impact of COVID-19 on IPF patients, necessitating proactive measures, vaccination, and comprehensive management.
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How to Cite
Cavasin, Davide, Umberto Zanini, Laura Montelisciani, Maria Grazia Valsecchi, Laura Fabbri, Laura Antolini, and Fabrizio Luppi. 2024. “ The Impact of COVID-19 Infection on Idiopathic Pulmonary Fibrosis Mortality: A Systematic Review and Meta-Analysis”. Monaldi Archives for Chest Disease, October. https://doi.org/10.4081/monaldi.2024.3070.
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