https://doi.org/10.4081/monaldi.2024.3196
Prescription patterns and drug utilization in respiratory tract infections: implications for antimicrobial stewardship at a tertiary care teaching hospital
Submitted: September 6, 2024
Accepted: September 26, 2024
Published: December 23, 2024
Accepted: September 26, 2024
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PDF_EARLY VIEW: 135
SUPPLEMENTARY MATERIAL: 11
SUPPLEMENTARY MATERIAL: 11
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Respiratory tract infections (RTIs) are common causes of hospital admissions and are often treated with multiple medications, including antibiotics, contributing to antimicrobial resistance. Effective drug utilization evaluation (DUE) is essential for ensuring rational drug use in RTI management. This study aimed to assess prescription patterns and drug utilization in RTI patients at a tertiary care hospital, focusing on the rationality of drug use, polypharmacy, adherence to clinical guidelines, and implications for antimicrobial stewardship. A cross-sectional study was conducted at Vivekananda General Hospital, Hubballi, India, from August 2023 to January 2024. Data from 200 RTI inpatients, including demographics, medication types, administration routes, and prescription patterns, were analyzed. Descriptive and inferential statistics were used to evaluate adherence to guidelines and rational drug use. DUE revealed that 50.99% of patients were not prescribed cough syrup. Oral (52%) and intravenous (48%) routes were the most common. Budesonide was the most frequently prescribed bronchodilator (26.49%), and 72.45% of patients received oxygen. Ceftriaxone (12.68%) and azithromycin (11.88%) were the most commonly prescribed antibiotics. A high prevalence of polypharmacy was identified, with 39.50% of patients receiving more than three antibiotics, raising concerns about drug interactions and rationality. The study underscores the need for stricter adherence to clinical guidelines and targeted antimicrobial stewardship in RTI management. Enhanced DUE practices could improve patient outcomes and promote rational drug use.
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Ethics Approval
The study's purpose was conveyed to the patients and their families. The patients provided written informed consent. The KLE College of Pharmacy Ethical Committee gave its approval to the study. (IEC Reference Number: KLECOPH/IEC/2023- 24/08).How to Cite
Dsouza, Princy Domnic, Sai Phalguna Prakash Chitralu, Chandrashekhar Mallikarjun Patil, Vinod Ashok Koujalagi, and Sanatkumar Bharamu Nyamagoud. 2024. “Prescription Patterns and Drug Utilization in Respiratory Tract Infections: Implications for Antimicrobial Stewardship at a Tertiary Care Teaching Hospital”. Monaldi Archives for Chest Disease, December. https://doi.org/10.4081/monaldi.2024.3196.
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