https://doi.org/10.4081/monaldi.2024.3203
Diffuse alveolar hemorrhage: a retrospective study from a tertiary care center
Submitted: September 13, 2024
Accepted: September 17, 2024
Published: October 28, 2024
Accepted: September 17, 2024
Abstract Views: 195
PDF_EARLY VIEW: 30
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Diffuse alveolar hemorrhage (DAH) is characterized by a syndrome of alveolar bleeding, a fall in hemoglobin, and respiratory failure. It can occur because of various immunologic and non-immunologic conditions. The etiology of DAH is important, as treatment varies with the etiology. This retrospective observational study evaluates the diverse etiologies, time to diagnosis from symptom onset, management strategies, and outcome of DAH in a span of 12 months at our tertiary care center. A total of 8 patients were identified with 8 different etiologies. 6/8 (75%) patients had immunologic causes, and 2/8 (25%) had non-immunologic causes of DAH. 6/8 (75%) patients were females, the mean time to DAH diagnosis was 4.25 months from symptom onset, 6/8 (75%) patients improved, and 2/8 (25%) died due to complications. It is necessary to differentiate between the etiologies of DAH and establish an early diagnosis to plan management and improve outcomes.
Lara AR, Schwarz MI. Diffuse alveolar hemorrhage. Chest 2010;137:1164-71.
DOI: https://doi.org/10.1378/chest.08-2084
Gallagher H, Kwan JT, Jayne DR. Pulmonary renal syndrome: a 4-year, single-center experience. Am J Kidney Dis 2002;39:42-7.
DOI: https://doi.org/10.1053/ajkd.2002.29876
Quadrelli S, Dubinsky D, Solis M, et al. Immune diffuse alveolar hemorrhage: clinical presentation and outcome. Respir Med 2017;129:59-62.
DOI: https://doi.org/10.1016/j.rmed.2017.06.003
Collard HR, Schwarz MI. Diffuse alveolar hemorrhage. Clin Chest Med 2004;25:583-92.
DOI: https://doi.org/10.1016/j.ccm.2004.04.007
Park MS. Diffuse alveolar hemorrhage. Tuberc Respir Dis 2013;74:151-62.
DOI: https://doi.org/10.4046/trd.2013.74.4.151
de Prost N, Parrot A, Picard C, et al. Diffuse alveolar haemorrhage: factors associated with in-hospital and long-term mortality. Eur Respir J 2010;35:1303-11.
DOI: https://doi.org/10.1183/09031936.00075309
Alexandre AT, Vale A, Gomes T. Diffuse alveolar hemorrhage: How relevant is etiology? Sarcoidosis Vasc Diffuse Lung Dis 2019;36:47-52.
lbelda SM, Gefter WB, Epstein DM, Miller WT. Diffuse pulmonary hemorrhage: a review and classification. Radiology 1985;154:289-97.
DOI: https://doi.org/10.1148/radiology.154.2.3155569
Kumasaka S, Kumasaka Y, Jingu A, Tsushima Y. Diagnostic value of “hyperdense consolidation sign” as a characteristic new computed tomography sign of diffuse alveolar hemorrhage. Sci Rep 2022;12:21143.
DOI: https://doi.org/10.1038/s41598-022-25740-y
Garcia D, Erkan D. Diagnosis and management of the antiphospholipid syndrome. N Engl J Med 2018;378:2010-21.
DOI: https://doi.org/10.1056/NEJMra1705454
Yachoui R, Sehgal R, Amlani B, Goldberg JW. Antiphospholipid antibodies-associated diffuse alveolar hemorrhage. Semin Arthritis Rheum 2015;44:652-7.
DOI: https://doi.org/10.1016/j.semarthrit.2014.10.013
Deane KD, West SG. Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: a case series and literature review. Semin Arthritis Rheum 2005;35:154-65.
DOI: https://doi.org/10.1016/j.semarthrit.2005.05.006
Scheiman Elazary A, Cohen MJ, Aamar S, et al. Pulmonary hemorrhage in antiphospholipid antibody syndrome. J Rheumatol 2012;39:1628-31.
DOI: https://doi.org/10.3899/jrheum.120205
Cartin-Ceba R, Peikert T, Ashrani A, et al. Primary antiphospholipid syndrome–associated diffuse alveolar hemorrhage. Arthritis Care Res 2014;66:301-10.
DOI: https://doi.org/10.1002/acr.22109
Onuk T, İpek G, Karataş MB, et al. Diffuse alveolar hemorrhage after clopidogrel use. Balkan Med J 2016;33:719-20.
DOI: https://doi.org/10.5152/balkanmedj.2016.151545
Soriano R, Al-Rawaf S, Diab K. Diffuse alveolar haemorrhage: a rare complication of clopidogrel use. BMJ Case Rep 2021;14:e244314.
DOI: https://doi.org/10.1136/bcr-2021-244314
Khilnani GC, Tiwari P, Goyal A, Singh L, Arora A, Guleria R. A rare case of pulmonary alveolar hemorrhage with cardiomyopathy. Chest 2018;142:463A.
DOI: https://doi.org/10.1378/chest.1389689
Saha BK. Idiopathic pulmonary hemosiderosis: A state of the art review. Respir Med 2021;176:106234.
DOI: https://doi.org/10.1016/j.rmed.2020.106234
Iwasaki K, Matsuzawa Y, Wakabayashi H, et al Diffuse alveolar haemorrhage with suspected idiopathic pulmonary hemosiderosis and decrease in lung diffusing capacity and chronic respiratory failure BMJ Case Rep 2021;14:e242901.
DOI: https://doi.org/10.1136/bcr-2021-242901
Zamora MR, Warner ML, Tuder R, Schwarz MI. Diffuse alveolar hemorrhage and systemic lupus erythematosus: clinical presentation, histology, survival, and outcome. Medicine 1997;76:192-202.
DOI: https://doi.org/10.1097/00005792-199705000-00005
de Prost N, Parrot A, Cuquemelle E, et al. Diffuse alveolar hemorrhage in immunocompetent patients: etiologies and prognosis revisited. Respir Med 2021;106:1021-32.
DOI: https://doi.org/10.1016/j.rmed.2012.03.015
How to Cite
Mohan, Sanchit, Rohit Kumar, Pranav Ish, Rajnish Kaushik, Tanmaya Talukdar, Neeraj Gupta, and Nitesh Gupta. 2024. “Diffuse Alveolar Hemorrhage: A Retrospective Study from a Tertiary Care Center”. Monaldi Archives for Chest Disease, October. https://doi.org/10.4081/monaldi.2024.3203.
Copyright (c) 2024 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Bhupen Barman, Arvind Nune, Pranav Ish, Pranjal Phukan, Donboklang Lynser, Hem Raj Sapkota, Complete persistent remission of rheumatoid arthritis after COVID-19 infection - A rare case and literature review , Monaldi Archives for Chest Disease: Vol. 93 No. 1 (2023)
- Lucrezia De Michele, Paola Pierucci, Guido Giovannetti, Arnaldo Scardapane, Carlo D'agostino, Giovanna Elisiana Carpagnano, Authors’ response to the Letter to the Editor regarding: Post severe COVID-19 infection lung damages study. The experience of early three months multidisciplinary follow-up , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Maya Gopalakrishnan, Satyendra Khichar, Suman Saurabh, Parag Vijayvergia, Karthikeyan Thangaraju, Swapnil Tripathi, Harshavardhan V. Devarakonda, Akhilesh Kumar , Pranav S. Kumar, Mahendra Kumar Garg , Effectiveness of early awake self proning strategy in non-intubated patients with COVID-19 hypoxemia: an open-labelled randomized clinical trial from Jodhpur, India , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
- Emanuele Stirpe, Floriana Bardaro, Alpha1-antitrypsin deficiency and asthma , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
You may also start an advanced similarity search for this article.
