https://doi.org/10.4081/monaldi.2024.3210
Prevalence and predictors of suboptimal peak inspiratory flow rates in the management of chronic obstructive pulmonary disease
Submitted: September 24, 2024
Accepted: October 18, 2024
Published: December 24, 2024
Accepted: October 18, 2024
Abstract Views: 28
PDF_EARLY VIEW: 8
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
This cross-sectional study aimed to investigate the role of peak inspiratory flow rate (PIFR) in the management of inhalation therapy for patients with chronic obstructive pulmonary disease (COPD). Conducted in the Department of Pulmonary Medicine at a tertiary care institute from July 2021 to January 2022, this study included a total of 351 patients who were clinically diagnosed with stable COPD and currently receiving inhaler therapy. Participants underwent comprehensive assessments that included demographic data collection, the use of the ABCD assessment tool to evaluate disease severity, the COPD Assessment Test (CAT) for quality of life measurement, and assessments for adherence to inhaler therapy and inhaler technique proficiency. The primary focus was on determining the prevalence of suboptimal PIFR and identifying associated demographic and clinical factors. The results indicated that 45% of the patients exhibited suboptimal PIFR, which is critical for effective medication delivery in COPD management. Analysis revealed several significant predictors of suboptimal PIFR: female gender, lower CAT scores, the type of inhaler device used, and a Modified Medical Research Council grade of ≥2, which indicates increased levels of breathlessness. These findings underscore the importance of assessing PIFR in COPD patients to ensure effective drug delivery. The study suggests that personalized inhaler device prescriptions tailored to individual PIFR can enhance treatment efficacy and improve overall management outcomes for COPD patients. By addressing factors contributing to suboptimal PIFR, healthcare providers can optimize inhalation therapy and ultimately improve patient quality of life.
Adeloye D, Song P, Zhu Y, et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modeling analysis. Lancet Respir Med 2022;10:447-58.
DOI: https://doi.org/10.1016/S2213-2600(21)00511-7
World Health Organization. Projections of mortality and causes of death, 2016 and 2060. Available from: https://colinmathers.com/2022/05/10/projections-of-global-deaths-from-2016-to-2060/. Accessed: July 2023.
India State-Level Disease Burden Initiative CRD Collaborators. The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990-2016. Lancet Glob Health 2018;6:e1363-74.
Newman SP. Principles of metered-dose inhaler design. Respir Care 2005;50:1177-90.
Janssens W, VandenBrande P, Hardeman E, et al. Inspiratory flow rates at different levels of resistance in elderly COPD patients. Eur Respir J 2008;31:78-83.
DOI: https://doi.org/10.1183/09031936.00024807
Mahler DA, Waterman LA, Ward J, et al. Comparison of dry powder versus nebulized beta-agonist in patients with COPD who have suboptimal peak inspiratory flow rate. J Aerosol Med Pulm Drug Deliv 2014;27:103-9.
DOI: https://doi.org/10.1089/jamp.2013.1038
Sharma G, Mahler DA, Mayorga VM, et al. Prevalence of low peak inspiratory flow rate at discharge in patients hospitalized for COPD exacerbation. Chronic Obstr Pulm Dis 2017;4:217-24.
DOI: https://doi.org/10.15326/jcopdf.4.3.2017.0183
Harb HS, Laz NI, Rabea H, et al. Prevalence and predictors of suboptimal peak inspiratory flow rate in COPD patients. Eur J Pharm Sci 2020;147:105298.
DOI: https://doi.org/10.1016/j.ejps.2020.105298
Ghosh S, Pleasants RA, Ohar JA, et al. Prevalence and factors associated with suboptimal peak inspiratory flow rates in COPD. Int J Chron Obstruct Pulmon Dis 2019;14:585-95.
DOI: https://doi.org/10.2147/COPD.S195438
Loh CH, Lovings TM, Ohar JA. Low inspiratory flow rates predict COPD and all-cause readmissions, in A23. Understanding and reducing copd rehospitalizations. Available from: https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2016.193.1_MeetingAbstracts.A1125.
Ghosh S, Pleasants RA, Donohue JF, et al. Device-specific suboptimal peak inspiratory flow rates are common in chronic obstructive pulmonary disease, in B33. COPD: maintenance therapy. 2018, Am J Respir Crit Care Med 2008;197:A3034.
Mahler DA, Waterman LA, Gifford AH. Prevalence and COPD phenotype for a suboptimal peak inspiratory flow rate against the simulated resistance of the Diskus® dry powder inhaler. J Aerosol Med Pulm Drug Deliv 2013;26:174-9.
DOI: https://doi.org/10.1089/jamp.2012.0987
Loh CH, Ohar JA. Personalization of device therapy–prime time for peak inspiratory flow rate. Chronic Obstr Pulm Dis 2017;4:172-6.
DOI: https://doi.org/10.15326/jcopdf.4.3.2017.0155
Loh CH Peters SP, Lovings TM, Ohar JA. Suboptimal inspiratory flow rates are associated with chronic obstructive pulmonary disease and all-cause readmissions. Ann Am Thorac Soc 2017;14:1305-11.
DOI: https://doi.org/10.1513/AnnalsATS.201611-903OC
Hua JL, Ye XF, Du CL, et al. Optimizing inhalation therapy in the aspect of peak inhalation flow rate in patients with chronic obstructive pulmonary disease or asthma. BMC Pulm Med 2021;21:302.
DOI: https://doi.org/10.1186/s12890-021-01674-5
Parekh AB, Kshatriya MR, Khara NV, et al. Inspiratory capacity in chronic obstructive pulmonary disease: a measure of hyperinflation and relation with other parameters – a cross-sectional study. Indian J Respir Care 2018;7:93-6.
DOI: https://doi.org/10.4103/ijrc.ijrc_2_18
Samarghandi A, Ioachimescu OC, Qayyum R. Association between peak inspiratory flow rate and hand grip muscle strength in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease. PLoS One 2020;15:e0227737.
DOI: https://doi.org/10.1371/journal.pone.0227737
Duarte A, Tung L, Hsu ES, et al. Spirometry measurement of peak inspiratory flow identifies suboptimal use of dry powder inhalers in ambulatory patients with COPD. Chronic Obstr Pulm Dis 2019;6:246-55.
DOI: https://doi.org/10.15326/jcopdf.6.3.2018.0163
Ethics Approval
The study protocol was approved by the Institute Scientific Committee, Institute ethics committee (JIP/IEC/2021/063).How to Cite
Mohapatra, Madhusmita Mohanty, Mahesh Babu Vemuri, Vinod Kumar Saka, Pratap Upadhya, and Vishnukanth Govindharaj. 2024. “Prevalence and Predictors of Suboptimal Peak Inspiratory Flow Rates in the Management of Chronic Obstructive Pulmonary Disease”. Monaldi Archives for Chest Disease, December. https://doi.org/10.4081/monaldi.2024.3210.
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