https://doi.org/10.4081/monaldi.2025.3223
Virtual bronchoscopic navigation and guided radial endobronchial ultrasound for peripheral pulmonary lesions: harmonizing modalities to optimize accuracy
Submitted: October 11, 2024
Accepted: November 29, 2024
Published: January 29, 2025
Accepted: November 29, 2024
Abstract Views: 35
PDF_EARLY VIEW: 17
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Peripheral pulmonary lesions (PPLs) present a significant diagnostic challenge due to their location beyond the reach of traditional bronchoscopy. With lung cancer being the leading cause of cancer-related mortality worldwide, accurate and early diagnosis of PPLs is crucial. Virtual bronchoscopic navigation (VBN) combined with radial endobronchial ultrasound (R-EBUS) has emerged as a promising technique to enhance the diagnostic yield for these lesions. This retrospective observational study evaluated the diagnostic yield of VBN-guided R-EBUS in patients with PPLs identified on computed tomography. The study included nine patients who underwent VBN-guided R-EBUS biopsy sampling. Patient demographics, lesion characteristics, and procedural outcomes were analyzed using descriptive and inferential statistics. The mean age of the patients was 57.33 years, with a mean lesion size of 3.24 cm. The diagnostic yield of VBN-guided R-EBUS was 77.7% (95% confidence interval: 68.5-85.8%). Non-small cell carcinoma was the most frequent histopathological diagnosis (55.5%). Complications included bleeding in two patients (22.2%) and bronchospasm in one patient (11.1%), all managed conservatively. VBN-guided R-EBUS provides high diagnostic accuracy and a low risk of complications in patients with PPLs.
Faurschou P, Milman N, Dirksen A, et al. Classification of pulmonary lesions into central and peripheral with a template applied on chest X-ray. Respir Med 1996;90:349-52.
DOI: https://doi.org/10.1016/S0954-6111(96)90131-6
Giri M, Dai H, Puri A, et al. Advancements in navigational bronchoscopy for peripheral pulmonary lesions: a review with special focus on virtual bronchoscopic navigation. Front Med 2022;9:989184.
DOI: https://doi.org/10.3389/fmed.2022.989184
Khan T, Usman Y, Abdo T, et al. Diagnosis and management of peripheral lung nodule. Ann Transl Med 2019;7:348.
DOI: https://doi.org/10.21037/atm.2019.03.59
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209-49.
DOI: https://doi.org/10.3322/caac.21660
Singh N, Agrawal S, Jiwnani S, et al. Lung cancer in India. J Thorac Oncol 2021;16:1250-66.
DOI: https://doi.org/10.1016/j.jtho.2021.02.004
Gould MK, Fletcher J, Iannettoni MD, et al. Evaluation of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007;132:108S-30S.
DOI: https://doi.org/10.1378/chest.07-1353
Rivera MP, Mehta AC, Wahidi MM. Establishing the diagnosis of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013;143:e142S-65S.
DOI: https://doi.org/10.1378/chest.12-2353
Jacomelli M, Demarzo SE, Cardoso PFG, et al. Radial-probe EBUS for the diagnosis of peripheral pulmonary lesions. J Bras Pneumol 2016;42:248-53.
DOI: https://doi.org/10.1590/s1806-37562015000000079
Sainz Zuñiga PV, Vakil E, Molina S, et al. Sensitivity of radial endobronchial ultrasound-guided bronchoscopy for lung cancer in patients with peripheral pulmonary lesions: an updated meta-analysis. Chest 2020;157:994-1011.
DOI: https://doi.org/10.1016/j.chest.2019.10.042
Herth FJF, Eberhardt R, Becker HD, Ernst A. Endobronchial ultrasound-guided transbronchial lung biopsy in fluoroscopically invisible solitary pulmonary nodules: a prospective trial. Chest 2006;129:147-50.
DOI: https://doi.org/10.1378/chest.129.1.147
Kim SH, Kim MH, Lee MK, Eom JS. Problems in the pathologic diagnosis of suspected lung cancer. Tuberc Respir Dis 2023;86:176-82.
DOI: https://doi.org/10.4046/trd.2022.0142
Giri M, Puri A, Wang T, et al. Virtual bronchoscopic navigation versus non-virtual bronchoscopic navigation assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: a systematic review and meta-analysis. Ther Adv Respir Dis 2021;15:17534666211017048.
DOI: https://doi.org/10.1177/17534666211017048
Xu C, Yuan Q, Wang Y, et al. Usefulness of virtual bronchoscopic navigation combined with endobronchial ultrasound guided transbronchial lung biopsy for solitary pulmonary nodules. Medicine 2019;98:e14248.
DOI: https://doi.org/10.1097/MD.0000000000014248
Ishida T, Asano F, Yamazaki K, et al. Virtual bronchoscopic navigation combined with endobronchial ultrasound to diagnose small peripheral pulmonary lesions: a randomised trial. Thorax 2011;66:1072-7.
DOI: https://doi.org/10.1136/thx.2010.145490
Han Y, Kim HJ, Kong KA, et al. Diagnosis of small pulmonary lesions by transbronchial lung biopsy with radial endobronchial ultrasound and virtual bronchoscopic navigation versus CT-guided transthoracic needle biopsy: a systematic review and meta-analysis. PloS One 2018;13:e0191590.
DOI: https://doi.org/10.1371/journal.pone.0191590
Callister MEJ, Baldwin DR, Akram AR, et al. British Thoracic Society guidelines for the investigation and management of pulmonary nodules. Thorax 2015;70:ii1-54.
DOI: https://doi.org/10.1136/thoraxjnl-2015-207168
Dhillon SS, Harris K. Bronchoscopy for the diagnosis of peripheral lung lesions. J Thorac Dis 2017;9:S1047-58.
DOI: https://doi.org/10.21037/jtd.2017.05.48
Levine MZ, Goodman S, Lentz RJ, et al. Advanced bronchoscopic technologies for biopsy of the pulmonary nodule: a 2021 review. Diagnostics 2021;11:2304.
DOI: https://doi.org/10.3390/diagnostics11122304
Ganaie B, Denny N, Mills J, Munavvar M. Comparison of radial mini probe endobronchial ultrasound with and without virtual bronchoscopic navigation to sample peripheral pulmonary lesions; a retrospective analysis. Eur Respir J 2016;48:PA4672.
DOI: https://doi.org/10.1183/13993003.congress-2016.PA4672
Tian S, Li X, Liu J, Wang X, et al. Radial endobronchial ultrasound - guided bronchoscopy for the diagnosis of peripheral pulmonary lesions: a systematic review and meta-analysis of prospective trials. Heliyon 2024;10:e29446.
DOI: https://doi.org/10.1016/j.heliyon.2024.e29446
Prado RMG, Cicenia J, Almeida FA. Robotic-assisted bronchoscopy: a comprehensive review of system functions and analysis of outcome data. Diagnostics 2024;14:399.
DOI: https://doi.org/10.3390/diagnostics14040399
Verhoeven RLJ, Kops SEP, Wijma IN, et al. Cone-beam CT in lung biopsy: a clinical practice review on lessons learned and future perspectives. Ann Transl Med 2023;11:361.
DOI: https://doi.org/10.21037/atm-22-2845
Jain A, Sarkar A, Husnain SMN, et al. Digital tomosynthesis: review of current literature and its impact on diagnostic bronchoscopy. Diagnostics 2023;13:2580.
DOI: https://doi.org/10.3390/diagnostics13152580
How to Cite
Mrigpuri, Parul, Sidharth Raj Yadav, Divyendu Sharma, Sonam Spalgais, Vidushi Rathi, Nitin Goel, Balakrishnan Menon, and Raj Kumar. 2025. “Virtual Bronchoscopic Navigation and Guided Radial Endobronchial Ultrasound for Peripheral Pulmonary Lesions: Harmonizing Modalities to Optimize Accuracy”. Monaldi Archives for Chest Disease, January. https://doi.org/10.4081/monaldi.2025.3223.
Copyright (c) 2025 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Matteo Bonini, Paolo Palange, Roflumilast is safe and effective in improving symptoms and lung function in severe COPD , Monaldi Archives for Chest Disease: Vol. 79 No. 3-4 (2013): Pulmonary series - Supplement 1
- Manu Dogra, Surabhi Jaggi, Deepak Aggarwal, Seema Gupta, Varinder Saini, Jasbinder Kaur, Role of interleukin-6 and insulin resistance as screening markers for metabolic syndrome in patients of chronic obstructive pulmonary disease. A hospital-based cross-sectional study , Monaldi Archives for Chest Disease: Vol. 92 No. 3 (2022)
- H. Bhardwaj, B. Bhardwaj, P.V. Carlile, Recurrent pneumomediastinum in a patient with rheumatoid arthritis , Monaldi Archives for Chest Disease: Vol. 79 No. 3-4 (2013): Pulmonary series
- S. Conforti, M. Torre, S. Fieschi, A. Lomonaco, M. Ravini, Successful treatment of persistent postoperative air leaks following the placement of an endobronchial one-way valve , Monaldi Archives for Chest Disease: Vol. 73 No. 2 (2010): Pulmonary series
- G. Garuti, G. Bandiera, M.S. Cattaruzza, L. Gelati, J.F. Osborn, S. Toscani, M. Confalonieri, M. Lusuardi, Out-of-hospital helmet CPAP in acute respiratory failure reduces mortality: a study led by nurses , Monaldi Archives for Chest Disease: Vol. 73 No. 4 (2010): Pulmonary series
- B. Singh, S. Arora, V. Khanna, Association of severity of COPD with IgE and interleukin-1beta , Monaldi Archives for Chest Disease: Vol. 73 No. 2 (2010): Pulmonary series
- E. Bacci, L. Melosini, F. Novelli, S. Marinaro, A.P. Pala, A. Angino, F.L. Dente, P. Paggiaro, Are Italian Pulmonologists aware of the Guidelines for asthma management and do they know how to apply them? , Monaldi Archives for Chest Disease: Vol. 75 No. 2 (2011): Pulmonary series
- S. La Grutta, G. Nicolini, C. Capristo, S.C. Bellodi, G.A. Rossi, Once daily nebulized beclomethasone is effective in maintaining pulmonary function and improving symptoms in asthmatic children , Monaldi Archives for Chest Disease: Vol. 67 No. 1 (2007): Pulmonary series
- Debasis Behera, J C Suri, Pranav Ish, Ruchi Rekha Behera, Shibdas Chakrabarti, Viswesvaran Balasubramanian, Role of esophageal manometry in polysomnography of patients with chronic respiratory failure , Monaldi Archives for Chest Disease: Vol. 91 No. 4 (2021)
- Donatella Ruggiero, Stefania Paolillo, Giuseppe Della Ratta, Antonio Mariniello, Tiziana Formisano, Angela Maria Pellegrino, Pasquale Perrone Filardi, Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications , Monaldi Archives for Chest Disease: Vol. 80 No. 3 (2013): Cardiac series
<< < 19 20 21 22 23 24 25 26 27 28 > >>
You may also start an advanced similarity search for this article.
