https://doi.org/10.4081/monaldi.2025.3231
The role of genetics in the prognosis of acute myocarditis: a systematic review and meta-analysis
Submitted: October 18, 2024
Accepted: December 10, 2024
Published: February 25, 2025
Accepted: December 10, 2024
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SUPPLEMENTARY MATERIAL: 15
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Myocarditis is a heterogeneous disease with varying clinical presentations, etiologies, and courses. Apart from environmental factors, genetic factors may also play a role in its pathophysiology. Through a systematic review and meta-analysis, we aimed to characterize the relationship between acute myocarditis (AM), underlying genetic background, and prognosis. We searched on MEDLINE/PubMed and Web of Science for studies reporting clinical outcomes of patients presenting with AM and undergoing genetic testing. The prevalence of a positive genetic test result was 27.3%, with a higher proportion of males (61.3%). Patients with a positive genetic test often had a family history of cardiovascular events (53.3%) and late gadolinium enhancement on cardiac magnetic resonance (81.2%), suggesting that these clinical features may represent a population with a higher burden of genetic background and risk for worse outcomes. The risk of recurrence of AM among patients with a positive genetic test was four times greater than among non-carriers (RR=4.02, p<0.001), and the most frequently observed variants among AM carriers were in the TTN, DSP, PKP2, MYH7, BAG3, RMB20, DSG2, TNNT2, and SCN5A genes. Overall, these findings underscore the need to improve the criteria used for genetic testing in the setting of AM episodes and to identify affected individuals who may benefit from increased surveillance and genetic testing.
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How to Cite
Tomás, Maria João, Ana Isabel Pinho, Bernardo Sousa Pinto, and Elisabete Martins. 2025. “The Role of Genetics in the Prognosis of Acute Myocarditis: A Systematic Review and Meta-Analysis”. Monaldi Archives for Chest Disease, February. https://doi.org/10.4081/monaldi.2025.3231.
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