https://doi.org/10.4081/monaldi.2025.3281
Bronchoscopic valve therapy for tuberculosis: a scoping review
Submitted: November 29, 2024
Accepted: January 8, 2025
Published: March 5, 2025
Accepted: January 8, 2025
Abstract Views: 328
PDF_EARLY VIEW: 100
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The management of tuberculosis (TB) presents significant challenges, particularly in the context of multidrug-resistant TB (MDR-TB) and TB-HIV co-infection. Traditional surgical interventions, such as lung resection and pneumothorax induction, have largely been phased out with the advent of modern antibiotic regimens. However, emerging evidence suggests that endobronchial interventions, specifically the use of unidirectional valves, have potential in supporting the treatment of MDR-TB. The objective of this review is to demonstrate the feasibility of closure of tubercular cavities using endobronchial valves, resulting in improved clinical outcomes and sputum smear conversion. PubMed was searched from inception to September 2024. The small studies reviewed here demonstrate the feasibility of tubercular cavity closure using endobronchial valves, resulting in improved clinical outcomes and sputum smear conversion. Yet, limited access to Food and Drug Administration-approved valves and funding challenges hinders large-scale trials. To address these limitations, further evidence is needed within improved international collaboration. We suggest that international prospective trials and innovation are needed. Such collaborative efforts would clarify the role of valves in TB treatment and hopefully lead to the development of simpler and more affordable occlusive devices that would benefit patients with MDR-TB, particularly in low-income countries.
World Health Organization. Global tuberculosis report: 2022. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022.
Marrone MT, Venkataramanan V, Goodman M, et al. Surgical interventions for drug-resistant tuberculosis: a systematic review and meta-analysis. Int J Tuberc Lung Dis 2013;17:6-16.
DOI: https://doi.org/10.5588/ijtld.12.0198
Calligaro GL, Moodley L, Symons G, Dheda K. The medical and surgical treatment of drug-resistant tuberculosis. J Thorac Dis 2014;6:186-95.
Drain PK, Bajema KL, Dowdy D, et al. Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection. Clin Microbiol Rev 2018;31:e00021-18.
DOI: https://doi.org/10.1128/CMR.00021-18
Paton NI, Cousins C, Suresh C, et al. Treatment strategy for rifampin-susceptible tuberculosis. N Engl J Med 2023;388:873-87.
DOI: https://doi.org/10.1056/NEJMoa2212537
WHO. WHO consolidated guidelines on tuberculosis: module 4: treatment - drug-susceptible tuberculosis treatment. 2022. Available from: https://www.who.int/publications/i/item/9789240048126.
Edessa D, Sisay M, Dessie Y. Unfavorable outcomes to second-line tuberculosis therapy among HIV-infected versus HIV-uninfected patients in sub-Saharan Africa: a systematic review and meta-analysis. PLoS One 2020;15:e0237534.
DOI: https://doi.org/10.1371/journal.pone.0237534
Kempker RR, Vashakidze S, Solomonia N, et al. Surgical treatment of drug-resistant tuberculosis. Lancet Infect Dis 2012;12:157-66.
DOI: https://doi.org/10.1016/S1473-3099(11)70244-4
Toma TP, Hopkinson NS, Hillier J, et al. Bronchoscopic volume reduction with valve implants in patients with severe emphysema. Lancet 2003;361:931-3.
DOI: https://doi.org/10.1016/S0140-6736(03)12762-6
Criner GJ, Wright S, Sue R, et al. Effectiveness of the zephyr® endobronchial valves (EBV®) in patients with severe emphysema: clinical outcomes from liberate, a multicenter RCT. Am J Respir Crit Care Med 2018;198:1151-64.
DOI: https://doi.org/10.1164/rccm.201803-0590OC
Corbetta L, Tofani A, Montinaro F, et al. Lobar collapse therapy using endobronchial valves as a new complementary approach to treat cavities in multidrug-resistant tuberculosis and difficult-to-treat tuberculosis: a case series. Respiration 2016;92:316-28.
DOI: https://doi.org/10.1159/000450757
Levin A, Sklyuev S, Felker I, et al. Endobronchial valve treatment of destructive multidrugresistant tuberculosis. Int J Tuberc Lung Dis 2016;20:1539-45.
DOI: https://doi.org/10.5588/ijtld.16.0033
An H, Liu X, Wang T, et al. Endobronchial valve treatment of tuberculous cavities in patients with multidrug-resistant pulmonary tuberculosis: a randomized clinical study. Pathogens 2022;11:899.
DOI: https://doi.org/10.3390/pathogens11080899
Popova LA, Shergina EA, Lovacheva OV, et al. Change in lung function early after endoscopic bronchial valve placement in patients with chronic cavitary tuberculosis. Pulmonologiya 2018;28:332-40.
DOI: https://doi.org/10.18093/0869-0189-2018-28-3-332-340
Popova LA, Shergina EA, Bagdasaryan TP, et al. The change of ventilation and gas exchange function of the lungs as the result of endoscopic valvular bronchial blocking in patients with recurrent fibro-cavernous tuberculosis after lung resection. Medical Alphabet 2019;3:8-15.
DOI: https://doi.org/10.33667/2078-5631-2019-3-29(404)-8-15
Togo T, Atsumi J, Hiramatsu M, et al. A novel approach to extensive clarithromycin-resistant mycobacterium avium complex pulmonary disease. Ann Thorac Cardiovasc Surg 2022;28:444-7.
DOI: https://doi.org/10.5761/atcs.cr.21-00010
Song X, Gu Y, Wang H, Zhang L. The efficacy of endobronchial valves for the treatment of bronchopleural fistula: a single-arm clinical trial. J Thorac Dis 2022;14:712-20.
DOI: https://doi.org/10.21037/jtd-22-258
Lalla U, Allwood BW, Sinha Roy S, et al. Endobronchial valve used as salvage therapy in a mechanically ventilated patient with intractable life-threatening haemoptysis. Respiration 2017;93:436-40.
DOI: https://doi.org/10.1159/000465526
Diab K, Rieger K, Noor A. Endobronchial valve placement for pulmonary tuberculosis-related bronchocutaneous fistula after thoracoplasty. J Bronchology Interv Pulmonol 2020;27:294-6.
DOI: https://doi.org/10.1097/LBR.0000000000000688
Gompelmann D, Dheda K. Endoscopic valve therapy: a new therapeutic approach for otherwise incurable tuberculosis? Respiration 2017;93:79-80.
DOI: https://doi.org/10.1159/000453621
How to Cite
Agarwal, Kshitij, Adam T. Gray, Tudor P. Toma, Valentina Luzzi, and Lorenzo Corbetta. 2025. “Bronchoscopic Valve Therapy for Tuberculosis: A Scoping Review”. Monaldi Archives for Chest Disease, March. https://doi.org/10.4081/monaldi.2025.3281.
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