Medication adherence and its effect on health-related quality of life in respiratory tract infection patients using the St. George’s Respiratory Questionnaire and the Medication Adherence Report Scale

Submitted: January 7, 2025
Accepted: January 27, 2025
Published: April 7, 2025
Abstract Views: 248
PDF_EARLY VIEW: 17
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Respiratory tract infections (RTIs) are common and pose significant health challenges, particularly in economically disadvantaged regions. Medication adherence is believed to influence patient quality of life (QoL), but the extent of this impact remains unclear. A cross-sectional study was conducted at Vivekananda General Hospital, Hubballi, India, from August 2023 to January 2024 to assess the relationship between medication adherence and QoL in RTI patients. This study involved 200 patients from the pulmonology department. Medication adherence was evaluated using the Medication Adherence Report Scale, while QoL was assessed with the St. George’s Respiratory Questionnaire (SGRQ). A two-way analysis of variance was performed to examine associations between adherence and QoL scores. No significant correlation was found between medication adherence and QoL. SGRQ total, symptoms, activity, and impact scores did not differ significantly between less adherent and highly adherent patients (p: 0.570-0.944). Medication adherence alone may not significantly affect QoL in RTI patients. Other factors, including disease severity, medication efficacy, comorbidities, and socioeconomic conditions, might have a greater influence. Further research is needed to explore these determinants and develop strategies to improve patient outcomes.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Montuschi P, Barnes PJ, Pauwels RA, et al. New perspectives in pharmacological treatment of chronic obstructive pulmonary disease. J Med Chem 2002;45:2639-52.
Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;163:1256-76. DOI: https://doi.org/10.1164/ajrccm.163.5.2101039
Jones PW, Quirk FH, Baveystock CM, et al. A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis 1992;145:1321-7. DOI: https://doi.org/10.1164/ajrccm/145.6.1321
Ståhl E, Lindberg A, Jansson SA, et al. Health-related quality of life is related to COPD disease severity. Health Qual Life Outcomes 2005;3:56. DOI: https://doi.org/10.1186/1477-7525-3-56
Miravitlles M, Anzueto A, Legnani D, et al. Patient’s perception of exacerbations of COPD—the PERCEIVE study. Respir Med 2003;101:453-60. DOI: https://doi.org/10.1016/j.rmed.2006.07.010
Jones PW, Harding G, Berry P, et al. Development and first validation of the COPD assessment test. Eur Respir J 2009;34:648-54. DOI: https://doi.org/10.1183/09031936.00102509
Celli BR, MacNee W, Buist AS, et al. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004;23:932-46. DOI: https://doi.org/10.1183/09031936.04.00014304
Buist AS, McBurnie MA, Menezes AM, et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 2007;370:741-50. DOI: https://doi.org/10.1016/S0140-6736(07)61377-4
Lam WY, Fresco P. Medication adherence measures: an overview. Biomed Res Int 2015;2015:217047. DOI: https://doi.org/10.1155/2015/217047
Cross AJ, Elliott RA, Petrie K, et al. Interventions for improving medication-taking ability and adherence in older adults prescribed multiple medications. Cochrane Database Syst Rev 2020;5:CD012419. DOI: https://doi.org/10.1002/14651858.CD012419.pub2
Venditti V, Bleve E, Morano S, et al. Gender-related factors in medication adherence for metabolic and cardiovascular health. Metabolites 2023;13:1087. DOI: https://doi.org/10.3390/metabo13101087
Duarte-de-Araújo A, Teixeira P, Hespanhol V, et al. COPD: understanding patients' adherence to inhaled medications. Int J Chron Obstruct Pulmon Dis 2018;13:2767-73. DOI: https://doi.org/10.2147/COPD.S160982
Güell R, Casan P, Sangenís M, et al. Quality of life in patients with chronic respiratory disease: the Spanish version of the Chronic Respiratory Questionnaire (CRQ). Eur Respir J 1998;11:55-60. DOI: https://doi.org/10.1183/09031936.98.11010055
Jüngst C, Gräber S, Simons S, et al. Medication adherence among patients with chronic diseases: a survey-based study in pharmacies. QJM 2019;112:505-12. DOI: https://doi.org/10.1093/qjmed/hcz058
Homętowska H, Świątoniowska-Lonc N, Klekowski J, et al. Treatment adherence in patients with obstructive pulmonary diseases. Int J Environ Res Public Health 2022;19:11573. DOI: https://doi.org/10.3390/ijerph191811573
Llor C, Hernández S, Bayona C, et al. A study of adherence to antibiotic treatment in ambulatory respiratory infections. Int J Infect Dis 2013;17:e168-72. DOI: https://doi.org/10.1016/j.ijid.2012.09.012
Boucquemont J, Pai ALH, Dharnidharka VR, et al. Gender differences in medication adherence among adolescent and young adult kidney transplant recipients. Transplantation 2019;103:798-806. DOI: https://doi.org/10.1097/TP.0000000000002359
Kim SJ, Kwon OD, Han EB, et al. Impact of number of medications and age on adherence to antihypertensive medications: a nationwide population-based study. Medicine 2019;98:e17825. DOI: https://doi.org/10.1097/MD.0000000000017825
Campbell NL, Boustani MA, Skopelja EN, et al. Medication adherence in older adults with cognitive impairment: a systematic evidence-based review. Am J Geriatr Pharmacother 2012;10:165-77. DOI: https://doi.org/10.1016/j.amjopharm.2012.04.004
Kvarnström K, Westerholm A, Airaksinen M, et al. Factors contributing to medication adherence in patients with a chronic condition: a scoping review of qualitative research. Pharmaceutics 2021;13:1100. DOI: https://doi.org/10.3390/pharmaceutics13071100
Ampofo AG, Khan E, Ibitoye MB. Understanding the role of educational interventions on medication adherence in hypertension: a systematic review and meta-analysis. Heart Lung 2020;49:537-47. DOI: https://doi.org/10.1016/j.hrtlng.2020.02.039
Law MR, Soumerai SB, Ross-Degnan D, et al. A longitudinal study of medication nonadherence and hospitalization risk in schizophrenia. J Clin Psychiatry 2008;69:47-53. DOI: https://doi.org/10.4088/JCP.v69n0107
Bryant J, McDonald VM, Boyes A, et al. Improving medication adherence in chronic obstructive pulmonary disease: a systematic review. Respir Res 2013;14:109. DOI: https://doi.org/10.1186/1465-9921-14-109
Hansen R, Seifeldin R, Noe L. Medication adherence in chronic disease: issues in posttransplant immunosuppression. Transplant Proc 2007;39:1287-300. DOI: https://doi.org/10.1016/j.transproceed.2007.02.074
Pan J, Yu H, Hu B, et al. Urban-rural difference in treatment adherence of chinese hypertensive patients. Patient Prefer Adherence 2022;16:2125-33. DOI: https://doi.org/10.2147/PPA.S377203
Tüzün H, Aycan S, İlhan MN. Impact of comorbidity and socioeconomic status on quality of life in patients with chronic diseases who attend primary health care centres. Cent Eur J Public Health 2015;23:188-94. DOI: https://doi.org/10.21101/cejph.a3990
Krska J, Morecroft CW, Poole H, Rowe PH. Issues potentially affecting quality of life arising from long-term medicines use: a qualitative study. Int J Clin Pharm 2013;35:1161-9. DOI: https://doi.org/10.1007/s11096-013-9841-5

Ethics Approval

The KLE College of Pharmacy Ethical Committee approved the study. The IEC Reference Number KLECOPH/IEC/2023-24/08.

How to Cite

Nyamagoud, Sanatkumar Bharamu, Sai Phalguna Prakash Chitralu, Princy Domnic Dsouza, Chandrashekhar Mallikarjun Patil, Vinod Ashok Koujalagi, and Agadi Hiremath Viswanatha Swamy. 2025. “Medication Adherence and Its Effect on Health-Related Quality of Life in Respiratory Tract Infection Patients Using the St. George’s Respiratory Questionnaire and the Medication Adherence Report Scale”. Monaldi Archives for Chest Disease, April. https://doi.org/10.4081/monaldi.2025.3338.

Similar Articles

<< < 81 82 83 84 85 86 

You may also start an advanced similarity search for this article.