https://doi.org/10.4081/monaldi.2017.805
Direct oral anticoagulants in patients undergoing cardioversion: insight from randomized clinical trials
Accepted: April 10, 2017
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Anticoagulation, reducing the risk of thromboembolic events in patients undergoing cardioversion, is a cornerstone of peri-cardioversion management in patients with atrial fibrillation. We aimed to analyse published data on the efficacy and safety of direct oral anticoagulants (DOACs) in patients undergoing cardioversion. We performed a systematic review of randomized prospective clinical trials (RCTs) comparing DOACs with warfarin and reporting data on post-cardioversion outcomes of interest. Outcomes of interest were stroke, systemic thromboembolic events and major bleeding. We reviewed a total of six RCTs including 3900 cardioversions performed using a DOAC for thromboembolic prophylaxis. These studies reported a low incidence overall of adverse outcomes associated with the use of DOACs (around 1% in all studies, except the ROCKET post-hoc study which included ablation procedures). The incidence rate of adverse events during DOAC treatment was found to be very similar to that observed with warfarin anticoagulation. In RCTs DOAC treatment in patients undergoing cardioversion appears to be effective and safe. However, because evidence in this clinical setting is still weak, observational reports could be useful in providing further data about peri-procedural outcomes.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Francesco Giallauria, Rosa Lucci, Francesco Pilerci, Anna De Lorenzo, Athanasio Manakos, Marianna Psaroudaki, Mariantonietta D’Agostino, Alessandra Vitelli, Luigi Maresca, Domenico Del Forno, Carlo Vigorito, Efficacy of Telecardiology in improving the results of Cardiac Rehabilitation after acute myocardial infarction , Monaldi Archives for Chest Disease: Vol. 66 No. 1 (2006): Cardiac series
- Roberto Cemin, Massimiliano Manfrin, Massimo Daves, Werner Rauhe, Aldo Pietro Maggioni, Ten years differences in recently onset atrial fibrillation and flutter incidence and management , Monaldi Archives for Chest Disease: Vol. 82 No. 3 (2014): Cardiac series
- Roberta Ancona, Salvatore Comenale Pinto, Pio Caso, Vito Di Palma, Francesca Pisacane, Alfonso Roberto Martiniello, Cesare Quarto, Nicla De Rosa, Carlo Pisacane, Raffaele Calabrò, Right atrial mass following transcatheter radiofrequency ablation for recurrent atrial fibrillation: thrombus, endocarditis or mixoma? , Monaldi Archives for Chest Disease: Vol. 72 No. 1 (2009): Cardiac series
- C. Ortolani, F. Agostinis, S. Amoroso, R. Ariano, A. Barbato, M. Bassi, G. Cadario, P. Campi, F. Cardinale, G. Ciprandi, R. D’Anneo, M. Di Gioacchino, V. Di Rienzo, A. Fiocchi, M. Galimberti, E. Galli, M. Giovannini, C. Incorvaia, S. La Grutta, C. Lombardi, F. Marcucci, G. Marseglia, M. Minelli, A. Musarra, E. Nettis, E. Novembre, G. Pajno, G. Patriarca, F. Pezzuto, P. Piras, S. Pucci, A. Romano, C. Romano, O. Quercia, G. Scala, D. Schiavino, G. Sforza, M. Tosca, S. Tripodi, F. Frati, Practice parameters for sublingual immunotherapy , Monaldi Archives for Chest Disease: Vol. 65 No. 1 (2006): Pulmonary series
- Paolo Biagi, Luigi Abate, Massimo Alessandri, Salvatore Bocchini, Valerio Verdiani, Giuseppe Pettinà , Carlo Nozzoli, Heart failure with preserved systolic function: prevalence and clinical features in a cohort of patients admitted to internal medicine units. The study PRESYF-HF Tuscany , Monaldi Archives for Chest Disease: Vol. 68 No. 3 (2007): Cardiac series
- Roberto Porta, Laura Comini, Luca Barbano, Luca Bianchi, Michele Vitacca, A case of obstructive sleep apnea syndrome associated with floppy eyelid syndrome: positive effect of CPAP therapy , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Halil Yanardag, Cuneyt Tetikkurt, Muammer Bilir, Clinical and prognostic significance of muscle biopsy in sarcoidosis , Monaldi Archives for Chest Disease: Vol. 88 No. 1 (2018)
- Francesco Giallauria, Teresa Paragliola, Francesco Pilerci, Domenico Del Forno, Anna De Lorenzo, Athanasio Manakos, Rosa Lucci, Marianna Psaroudaki, Mariantonietta D’Agostino, Carlo Vigorito, Role of smokers in the household and of cardiac rehabilitation in smoking behaviour after acute myocardial infarction , Monaldi Archives for Chest Disease: Vol. 64 No. 2 (2005): Cardiac series
- Stefano Fumagalli, Serena Boni, Simone Pupo, Marta Migliorini, Irene Marozzi, Eleonora Barghini, Flavia Sacco, Niccolò Marchionni, Rate-control vs rhythm-control of atrial fibrillation in elderly patients. From new, age-oriented outcomes to a more complex management strategy , Monaldi Archives for Chest Disease: Vol. 88 No. 2 (2018)
- Giuseppe Patti, Ludmilla Mantione, Edoardo Bressi, Antonio Bisignani, Efficacy and safety of oral anticoagulant therapy in frail patients with atrial fibrillation , Monaldi Archives for Chest Disease: Vol. 88 No. 2 (2018)
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
