https://doi.org/10.4081/monaldi.2018.975
The impairment of the Growth Hormone/Insulin-like growth factor 1 (IGF-1) axis in heart failure: A possible target for future therapy
Accepted: July 30, 2018
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Hormonal abnormalities are quite common in chronic heart failure (CHF). The most studied hormonal axis in CHF is the impairment of Growth Hormone (GH)/Insulin Growth Factor-1(IGF-1), which in turn is defined either by a blunted response to GH stimulation test or low serum IGF-1 values. Â Several independent groups reported that the presence of an abnormal GH/IGF-1 status in CHF is associated with a more severe disease, impaired functional capacity and reduced Survival rates. After the first encouraging results, double -blind controlled trials showed a neutral effect of the GH administration in patients. However, further studies reported positive results, when a GH-therapy is implemented only in those patients presenting a GH deficiency (replacement therapy).
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Gabriella Malfatto, Paola Cuoccio, Caterina Bizzi, Giovanna Branzi, Alessandra Villani, Francesco Della Rosa, Gianfranco Parati, Mario Facchini, What underlies NYHA class in elderly patients with heart failure? role of diastolic dysfunction, functional mitral regurgitation and abnormal ventilation during exercise , Monaldi Archives for Chest Disease: Vol. 72 No. 2 (2009): Cardiac series
- Gerson Cipriano Jr, Graziella França Bernardelli, Ross Arena, Luis Vicente Franco Oliveira, Francisco Valdez, João Nelson Rodrigues Branco, Cardio-respiratory responses of the 6-minute walk test in patients with refractory heart failure during the preoperative period for heart transplant surgery , Monaldi Archives for Chest Disease: Vol. 74 No. 2 (2010): Cardiac series
- Paolo Biagi, Luigi Abate, Heart failure, oxidative stress and allopurinol , Monaldi Archives for Chest Disease: Vol. 64 No. 1 (2005): Cardiac series
- Paolo Biagi, Luigi Abate, Massimo Alessandri, Salvatore Bocchini, Valerio Verdiani, Giuseppe Pettinà , Carlo Nozzoli, Heart failure with preserved systolic function: prevalence and clinical features in a cohort of patients admitted to internal medicine units. The study PRESYF-HF Tuscany , Monaldi Archives for Chest Disease: Vol. 68 No. 3 (2007): Cardiac series
- F.J. de Serres, M. Luisetti, I. Ferrarotti, I. Blanco, E. Fernández-Bustillo, Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles , Monaldi Archives for Chest Disease: Vol. 63 No. 3 (2005): Pulmonary series
- Massimiliano Polastri, Lara Pisani, Andrea Dell'Amore, Stefano Nava, Revolving door respiratory patients: A rehabilitative perspective , Monaldi Archives for Chest Disease: Vol. 87 No. 3 (2017)
- Alberto M. Marra, Andrea Salzano, Michele Arcopinto, Lucrezia Piccioli, Valeria Raparelli, The impact of gender in cardiovascular medicine: Lessons from the gender/sex-issue in heart failure , Monaldi Archives for Chest Disease: Vol. 88 No. 3 (2018)
- David Simoni, Martina Rafanelli, Andrea Ungar, Enrico Mossello, Niccolò Marchionni, Samuele Baldasseroni, Neurocognitive profile of patients with continuous flow Left Ventricular Assist Device , Monaldi Archives for Chest Disease: Vol. 82 No. 2 (2014): Cardiac series
- A.J. Lopes, T.T. Mafort, A. de Sá Ferreira, M.C. Santos de Castro, M. de Cássia Firmida, E. de Andrade Marques, Is the type of chronic pulmonary infection a determinant of lung function outcomes in adult patients with cystic fibrosis? , Monaldi Archives for Chest Disease: Vol. 77 No. 3-4 (2012): Pulmonary series
- Mahmood Shirzad, Abbasali Karimi, Seyed Hossein Ahmadi, Mehrab Marzban, Mokhtar Tazik, Hermineh Aramin, Predictors and Early Outcome of Prolonged Mechanical Ventilation in Contemporary Heart valve Surgery , Monaldi Archives for Chest Disease: Vol. 74 No. 1 (2010): Cardiac series
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
