https://doi.org/10.4081/monaldi.2018.981
A case of bleomycin-induced lung toxicity
Accepted: October 16, 2018
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
A 64-year-old female was admitted for dry cough, dyspnea, fever, loss of appetite, and weight loss. Past medical history revealed scoliosis, cholecystectomy, and Hodgkin lymphoma. ABG values were: pH: 7.42, pCO2: 40.2 mm Hg, pO2: 61.4 mm Hg. Chest CT showed cystic lesions, emphysema, ground glass, and reticular opacities. ABG values worsened under 8L/min nasal oxygen. The patient underwent bilevel positive airway pressure (BiPAP) and methylprednisolone 60 mg/day bid was commenced. The final diagnosis was respiratory insufficiency due to bleomycin toxicity. The patient deceased on the sixth day after transfer to the intensive care unit. Bleomycin is an effective chemotherapeutic agent used for Hodgkin lymphoma treatment. It causes significant lung toxicity in half of the patients. Clinicians should always remember that bleomycin toxicity may lead to fatal complications in patients with comorbid conditions. We present this case to remark the possible consequences of bleomycin toxicity and the precautions taken to preclude bleomycin-induced pulmonary complications are discussed.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Gianfranco Beghi, Antonio De Tanti, Paolo Serafini, Chiara Bertolino, Antonietta Celentano, Graziella Taormina, Monitoring of hospital acquired pneumonia in patients with severe brain injury on first access to intensive neurological rehabilitation: First year of observation , Monaldi Archives for Chest Disease: Vol. 88 No. 1 (2018)
- M. Fernandes, A. Cukier, N. Ambrosino, J.J. Leite, M.I. Zanetti Feltrim, Respiratory pattern, thoracoabdominal motion and ventilation in chronic airway obstruction , Monaldi Archives for Chest Disease: Vol. 67 No. 4 (2007): Pulmonary series
- S. Ricotti, P. Vitulo, L. Petrucci, T. Oggionni, C. Klersy, Determinants of quality of life after lung transplant: an Italian collaborative study , Monaldi Archives for Chest Disease: Vol. 65 No. 1 (2006): Pulmonary series
- P. Malhotra, R. Agarwal, D. Gupta, A.N. Aggarwal, Successful management of ARDS with bronchopleural fistula secondary to miliary tuberculosis using a conventional ventilator , Monaldi Archives for Chest Disease: Vol. 63 No. 3 (2005): Pulmonary series
- Pier Luigi Temporelli, Cardiopulmonary rehabilitation in patiens with heart failure and chronic pulmonary disease , Monaldi Archives for Chest Disease: Vol. 84 No. 1-2 (2015): Cardiac series
- Jadd Kebbe, Sai Yendamuri, Charles Roche, Kassem Harris, Samjot Singh Dhillon, Esophago-pulmonary fistula manifesting as recurrent pneumonias and migrating mediastinal calcifications , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Maria Rosario Piccirillo, Armando Natale, Giovanni Trosino, Marianna Sebastopoli, Giovanni Vivona, Giovanni De Martino, Gennaro Ismeno, Luigi Piazza, Luigi Belloni, What’s the best assessment of preload after cardiac surgery? , Monaldi Archives for Chest Disease: Vol. 64 No. 1 (2005): Cardiac series
- U. Caterino, G. Dialetto, F.E. Covino, G. Mazzarella, E. Grella, M. Massimo, The usefulness of transesophageal echocardiography in the staging of locally advanced lung cancer , Monaldi Archives for Chest Disease: Vol. 67 No. 1 (2007): Pulmonary series
- M. Vitacca, J. Escarrabill, G. Galavotti, A. Vianello, E. Prats, R. Scala, A. Peratoner, E. Guffanti, L. Maggi, L. Barbano, B. Balbi, Home mechanical ventilation patients: a retrospective survey to identify level of burden in real life , Monaldi Archives for Chest Disease: Vol. 67 No. 3 (2007): Pulmonary series
- R.W. Dal Negro, C. Micheletto, S. Tognella, C. Turati, R. Bisato, M. Guerriero, M. Sandri, P. Turco, PIKO-1, an effective, handy device for the patient’s personal PEFR and FEV1 electronic long-term monitoring , Monaldi Archives for Chest Disease: Vol. 67 No. 2 (2007): Pulmonary series
<< < 15 16 17 18 19 20 21 22 23 24 > >>
You may also start an advanced similarity search for this article.
