https://doi.org/10.4081/monaldi.2018.981

A case of bleomycin-induced lung toxicity

Vol. 88 No. 3 (2018)
Submitted: July 15, 2018
Accepted: October 16, 2018
Published: November 6, 2018
Bleomycin, bleomycin-induced lung toxicity, pulmonary fibrosis, bleomycin toxicity.
Abstract Views: 1630
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Authors

Cuneyt Tetikkurt
tetikkurt@gmail.com
https://orcid.org/0000-0002-4122-2908
Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department, Turkey.
Deniz Ongel
Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department, Turkey.
Seza Tetikkurt
University of Health Sciences, Bağcılar Training and Research Hospital, Department of Pathology, Turkey.

A 64-year-old female was admitted for dry cough, dyspnea, fever, loss of appetite, and weight loss. Past medical history revealed scoliosis, cholecystectomy, and Hodgkin lymphoma. ABG values were: pH: 7.42, pCO2: 40.2 mm Hg, pO2: 61.4 mm Hg. Chest CT showed cystic lesions, emphysema, ground glass, and reticular opacities. ABG values worsened under 8L/min nasal oxygen. The patient underwent bilevel positive airway pressure (BiPAP) and methylprednisolone 60 mg/day bid was commenced. The final diagnosis was respiratory insufficiency due to bleomycin toxicity. The patient deceased on the sixth day after transfer to the intensive care unit. Bleomycin is an effective chemotherapeutic agent used for Hodgkin lymphoma treatment. It causes significant lung toxicity in half of the patients. Clinicians should always remember that bleomycin toxicity may lead to fatal complications in patients with comorbid conditions. We present this case to remark the possible consequences of bleomycin toxicity and the precautions taken to preclude bleomycin-induced pulmonary complications are discussed.

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Cuneyt Tetikkurt, Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department

Pulmonary Diseases

 

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How to Cite

Tetikkurt, Cuneyt, Deniz Ongel, and Seza Tetikkurt. 2018. “A Case of Bleomycin-Induced Lung Toxicity”. Monaldi Archives for Chest Disease 88 (3). https://doi.org/10.4081/monaldi.2018.981.

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